Discrepant CD3+ TILs in PD-L1–Negative NSCLC: Favorable Outcome in an Elderly Patient Treated With Nivolumab, Ipilimumab, and Chemotherapy

Mataichi Sekiya; Munehide Nakatsugawa; Nobuyuki Koyama; Naohiro Kajiwara; Takuya Aoki

doi:10.12659/AJCR.951075

27 January 2026 : Case report Japan

Discrepant CD3+ TILs in PD-L1–Negative NSCLC: Favorable Outcome in an Elderly Patient Treated With Nivolumab, Ipilimumab, and Chemotherapy

Unusual clinical course, Unusual or unexpected effect of treatment

Mataichi Sekiya^{ABDEF 1*}, Munehide Nakatsugawa^{BCD 2}, Nobuyuki Koyama

^{ABD 1}, Naohiro Kajiwara^{ABD 3}, Takuya Aoki^{ABDEF 1}

DOI: 10.12659/AJCR.951075

Am J Case Rep 2026; 27:e951075

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Figure 1 Chest radiogram and fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT). The chest radiogram (A) and FDG-PET/CT (B) before treatment are shown. FDG-PET/CT revealed FDG accumulation in the left lower lobe and multiple lymph nodes, providing evidence of primary lung cancer and lymph node metastases, respectively.

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Discrepant CD3+ TILs in PD-L1–Negative NSCLC: Favorable Outcome in an Elderly Patient Treated With Nivolumab, Ipilimumab, and Chemotherapy

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