Discrepant CD3+ TILs in PD-L1–Negative NSCLC: Favorable Outcome in an Elderly Patient Treated With Nivolumab, Ipilimumab, and Chemotherapy

Mataichi Sekiya; Munehide Nakatsugawa; Nobuyuki Koyama; Naohiro Kajiwara; Takuya Aoki

doi:10.12659/AJCR.951075

27 January 2026 : Case report Japan

Discrepant CD3+ TILs in PD-L1–Negative NSCLC: Favorable Outcome in an Elderly Patient Treated With Nivolumab, Ipilimumab, and Chemotherapy

Unusual clinical course, Unusual or unexpected effect of treatment

Mataichi Sekiya^{ABDEF 1*}, Munehide Nakatsugawa^{BCD 2}, Nobuyuki Koyama

^{ABD 1}, Naohiro Kajiwara^{ABD 3}, Takuya Aoki^{ABDEF 1}

DOI: 10.12659/AJCR.951075

Am J Case Rep 2026; 27:e951075

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Figure 2 Serial CT images. Chest computed tomography (CT) before chemotherapy revealed a 64-mm mass in the left lower lobe (A). After the first course, the mass was reduced to a diameter of 59 mm (B). After the seventh course, shrinkage of the mass in the diameter of 38 mm was observed (C).

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Discrepant CD3+ TILs in PD-L1–Negative NSCLC: Favorable Outcome in an Elderly Patient Treated With Nivolumab, Ipilimumab, and Chemotherapy

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