Discrepant CD3+ TILs in PD-L1–Negative NSCLC: Favorable Outcome in an Elderly Patient Treated With Nivolumab, Ipilimumab, and Chemotherapy

Mataichi Sekiya; Munehide Nakatsugawa; Nobuyuki Koyama; Naohiro Kajiwara; Takuya Aoki

doi:10.12659/AJCR.951075

27 January 2026 : Case report Japan

Discrepant CD3+ TILs in PD-L1–Negative NSCLC: Favorable Outcome in an Elderly Patient Treated With Nivolumab, Ipilimumab, and Chemotherapy

Unusual clinical course, Unusual or unexpected effect of treatment

Mataichi Sekiya^{ABDEF 1*}, Munehide Nakatsugawa^{BCD 2}, Nobuyuki Koyama

^{ABD 1}, Naohiro Kajiwara^{ABD 3}, Takuya Aoki^{ABDEF 1}

DOI: 10.12659/AJCR.951075

Am J Case Rep 2026; 27:e951075

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Figure 4 Microscopic image of the tumor. Immunohistochemical detection using (A) anti-p40 and (B) anti-PD-L1. Scale bar, 50 μm. The squamous cell carcinoma showed p40 positivity but did not express PD-L1.

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Discrepant CD3+ TILs in PD-L1–Negative NSCLC: Favorable Outcome in an Elderly Patient Treated With Nivolumab, Ipilimumab, and Chemotherapy

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