10 February 2026
: Case report
Actinomycotic Cholecystitis and Pancreatitis: Report of an Unusual Case
Challenging differential diagnosis, Rare disease, Rare coexistence of disease or pathology
Carlos Eduardo Brantis-de-CarvalhoDOI: 10.12659/AJCR.951112
Am J Case Rep 2026; 27:e951112
Figure 3 Liver, canalicular, and pancreatic enzymes levels during hospitalization and initial outpatient follow-up. The figure depicts the trends in enzyme levels during hospitalization (days 1–14) and initial follow-up (day 18). The patient’s pancreatitis (the third episode for this patient), which began prior to hospitalization, evolved with improving enzyme levels (amylase and lipase) within 4 days (A). Pneumonia was diagnosed on the third day of hospitalization (B). An increase in liver and canalicular enzymes was observed on the ninth day (B), leading to the diagnosis of cholecystitis. Subsequent imaging evaluation of the gallbladder revealed biliary sludge, indicating the need for a cholecystectomy, which was performed on the tenth day (indicated by a vertical line in A, B). Post-surgery follow-up indicated an initial increase in enzyme levels, with a subsequent decrease within 4 days of the surgery (days 10–14). The decreased levels of these enzymes were maintained at the initial follow-up (day 18), with no further episodes of pancreatitis or elevated liver and canalicular enzymes being observed to the present moment (not shown). AST – aspartate aminotransferase; ALT – alanine aminotransferase; ALP – alkaline phosphatase; GGT – gamma-glutamyl transferase; ED – emergency department; ICU – intensive care unit; MW – medical ward.






