22 December 2025
: Case report 
Afebrile Recurrent Cellulitis Complicated by Linezolid-Induced Lactic Acidosis in an Elderly Patient
Unusual or unexpected effect of treatment, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)
Yanizbeth Yambó-Chévere BCDEF 1*, Rafael Bermúdez-Rivera BE 1,2DOI: 10.12659/AJCR.951194
Am J Case Rep 2025; 26:e951194
Figure 1 Timeline of the patient’s 4 hospitalizations over 6 months. Each horizontal line represents the duration of a hospitalization. Green “×” markers indicate admission dates; red “×” markers indicate discharges. Annotations summarize site of infection, organisms isolated, peak inflammatory markers (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]), and treatment regimens. Cumulative linezolid exposure across the first 3 hospitalizations totaled approximately 42 to 56 days and preceded the development of lactic acidosis during the fourth admission. All episodes were afebrile, with normal white blood cell counts.