02 May 2026
: Case report 
Co-Pathogenic Role of BRCA1 and OBSCN Deletions in Chinese Familial Breast Cancer: A Case Report
Unknown etiology
Lili Yi BCDE 1, Kexin Chen CEF 1, Dandan Wang C 2, Ruhao Wang D 1, Xiaoru Zhu C 2, Jian Chai G 1, Xiaodong Jia CD 1, Fei Xu DG 3, Mingliang Gu AG 1, Chuanyou Cui BE 4*, Wei Zhang ADE 5DOI: 10.12659/AJCR.951196
Am J Case Rep 2026; 27:e951196
Figure 5 (A) BRCA1: Ser 1841 and (B) The base sequence of OBSCN across species. (C, D) Schematic diagrams of the 3D protein structure of BRCA1 prior to and after the C > D mutation, which altered the amino acid at position 1334 from a serine to a valine. Red boxes indicate the amino acid at this site before and after mutation.