25 March 2026
: Case report 
Adult-Onset Nesidioblastosis: A Challenging Diagnosis Revealed by Endoscopic Ultrasonography
Challenging differential diagnosis, Rare disease
Kristína Cmarková AEF 1, Peter Uhrík ADE 2*, Roman Kyčina EF 1, Lenka Nosáková DEG 2, Miroslav Pindura DEF 1, Martin Grajciar AEF 1, Michal Kalman DE 3, Peter Bánovčin EFG 2, Juraj Miklušica DE 1DOI: 10.12659/AJCR.951251
Am J Case Rep 2026; 27:e951251
Figure 1 (A) Hematoxylin-eosin stain 20× magnification. Pancreatic tissue of our patient obtained during distal pancreatectomy showing Langerhans islet in the center (arrows) with an increased number of b cells exhibiting enlarged hyperchromatic nuclei and prominent nucleoli. The exocrine portion of pancreatic tissue shows no pathological findings (archive of the Department of Pathological Anatomy, University Hospital in Martin). (B) Hematoxylin-eosin stain 40× magnification. Magnified Langerhans islet with noticeable enlarged hyperchromatic nuclei and prominent nucleoli in b cells (archive of the Department of Pathological Anatomy, University Hospital in Martin).