24 April 2026
: Case report 
Diagnostic and Treatment Strategies for Adult Non-Ossifying Fibromas: A Case Report and Literature Review
Challenging differential diagnosis, Congenital defects / diseases
Zhibin Zhao BE 1, Jiawei Li C 1, Shaoke Wu ABEFG 1*DOI: 10.12659/AJCR.951665
Am J Case Rep 2026; 27:e951665
Figure 3 Hematoxylin and eosin (H&E) staining (×100) demonstrating spindle cells in a characteristic storiform (whorled) pattern with scattered osteoclast-like giant cells. Note the absence of significant cellular pleomorphism. High-power view (H&E, ×400) showing hemosiderin deposition and foam cell aggregates, consistent with previous hemorrhage and lipid-laden macrophages. Immunohistochemistry showing CD68 positivity in multinucleated giant cells, confirming their histiocytic origin. Ki-67 staining revealed a proliferative index of approximately 10% (inset), consistent with benign behavior. Scale bars: 100 μm.