Granulomatosis with Polyangiitis (Wegener Granulomatosis) Presenting as a Pancreatic Mass: A Rare Malignancy Mimic

Soumyadip Sain; Subhashish Das; Vinant Bhargava; Sunila Jain; Samiran Nundy

doi:10.12659/AJCR.951707

16 April 2026 : Case report India

Granulomatosis with Polyangiitis (Wegener Granulomatosis) Presenting as a Pancreatic Mass: A Rare Malignancy Mimic

Unusual clinical course, Challenging differential diagnosis, Unusual setting of medical care

Soumyadip Sain

^{ABEF 1*}, Subhashish Das^{ADF 1}, Vinant Bhargava^{BDF 2}, Sunila Jain^{BCD 3}, Samiran Nundy^{BCDEF 1}

DOI: 10.12659/AJCR.951707

Am J Case Rep 2026; 27:e951707

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Figure 2 Histopathology. (A) Pancreatic tissue, H&E stain, ×100. (B) Pancreatic tissue, H&E stain, ×400: Fragmented pancreatic tissue showing moderately dense acute-on-chronic inflammation of the stroma with fibrosis and acinar loss. Focal ductal hyperplasia with irregular cuboidal epithelial lining was noted. The inflammatory infiltrate is chiefly composed of lymphocytes, eosinophils, and neutrophils. H&E, hematoxylin and eosin.

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Granulomatosis with Polyangiitis (Wegener Granulomatosis) Presenting as a Pancreatic Mass: A Rare Malignancy Mimic

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