Figure 2 Visual observation and histomorphology of the tumor (hematoxylin and eosin staining). (A) A well-defined grayish-yellow mass with a cystic and solid pattern. (B) At low magnification, the tumor’s well-defined borders and thick fibrous capsule can be seen with extensive punctate necrosis within the tumor. (C) Desmoplastic reaction and inflammatory cell infiltration around periphery of the tumor. (D) Solid-papillary structures and necrosis. (E) Cribriform structure and necrosis. (F) Nuclei are enlarged, and have increased chromatin. The yellow arrows indicate mitotic activity. (G) The high-grade invasive component area outside the fibrous capsule of the tumor near the areola has greater cellular atypia (yellow arrows). (H) Low-grade invasive component in another area, the tumor cells showed little nuclear atypia, irregular arrangement of tumor cells, and inconspicuous nucleoli (yellow arrows). (I) An area of ductal carcinoma in situ can also be seen around the EPC with calcification. (Amplification: B, 100×; C–E, 200×; F–H, 400×; I, 200×)