05 April 2026
: Case report 
Methotrexate-Induced Encephalopathy Mimicking Acute Ischemic Stroke in an Adolescent With Osteosarcoma: A Case Report
Unusual clinical course, Mistake in diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease, Adverse events of drug therapy
Trinh Van Duong
ABCDEF 1,2*, Duong Thu Huong BDE 1, Khoa Quy BDF 2, Nguyen Thi Minh Phuong DF 1,2, Ha Quoc Hung EF 1,2
DOI: 10.12659/AJCR.951751
Am J Case Rep 2026; 27:e951751
Figure 2 Follow-up magnetic resonance imaging (MRI) on day 2. (A) Axial diffusion-weighted imaging shows resolution of the previous right-sided lesion and the appearance of a new focus of restricted diffusion in the left centrum semiovale, partially overlapping the prior lesion site. (B) Corresponding axial fluid-attenuated inversion recovery (FLAIR) sequence demonstrates a subtle, faint ring-like hyperintensity in the same left-sided region. Overall, FLAIR sequences remained largely unremarkable.