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22 April 2026 : Case report  China

Spinal Tuberculosis Diagnosed by Metagenomics Capture (MetaCAP) in a Patient Undergoing Maintenance Hemodialysis: A Case Report

Unusual clinical course, Challenging differential diagnosis

Mengyao Song CDEFG 1, Zheng Zhang BF 2, Haiyan Huang ORCID logo DF 3, Zhizhen Zou B 4, Sichun Wen ACDEF 5*, Yanhai Cui A 6, Shuangxin Liu A 7

DOI: 10.12659/AJCR.951840

Am J Case Rep 2026; 27:e951840

Figure 1 Timeline of the diagnosis and treatment process(A) Before treatment, T1WI shows hyper-intensity in T11-L5 vertebral bodies (red arrow); hypo-intensity in the L2 vertebral body (red arrow). (B) Before treatment, T2WI shows hyper-intensity in T11, L2, and L5 vertebral bodies (red arrow); mild flattening of the L2 vertebral body (red arrow). (C) L2 vertebral body biopsy pathology: fibrous and epithelial cell hyperplasia with mixed inflammatory infiltration and occasional multinucleated giant cells forming granulomas (black arrow). (D) Acid-fast staining of pathological tissue was negative. (E) After treatment, T2WI shows resolution of the prior hyper-intensity (red arrow). The hypo-intensity in the L2 vertebral body (red arrow) indicates reparative calcification. (F) After treatment, MRI shows resolution of the abnormal signal intensity in T11-L5 vertebral bodies (red arrow). The hypo-intensity in L2 (red arrow) is reparative calcification.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923