22 April 2026
: Case report
Spinal Tuberculosis Diagnosed by Metagenomics Capture (MetaCAP) in a Patient Undergoing Maintenance Hemodialysis: A Case Report
Unusual clinical course, Challenging differential diagnosis
Mengyao Song CDEFG 1, Zheng Zhang BF 2, Haiyan HuangDOI: 10.12659/AJCR.951840
Am J Case Rep 2026; 27:e951840
Figure 1 Timeline of the diagnosis and treatment process(A) Before treatment, T1WI shows hyper-intensity in T11-L5 vertebral bodies (red arrow); hypo-intensity in the L2 vertebral body (red arrow). (B) Before treatment, T2WI shows hyper-intensity in T11, L2, and L5 vertebral bodies (red arrow); mild flattening of the L2 vertebral body (red arrow). (C) L2 vertebral body biopsy pathology: fibrous and epithelial cell hyperplasia with mixed inflammatory infiltration and occasional multinucleated giant cells forming granulomas (black arrow). (D) Acid-fast staining of pathological tissue was negative. (E) After treatment, T2WI shows resolution of the prior hyper-intensity (red arrow). The hypo-intensity in the L2 vertebral body (red arrow) indicates reparative calcification. (F) After treatment, MRI shows resolution of the abnormal signal intensity in T11-L5 vertebral bodies (red arrow). The hypo-intensity in L2 (red arrow) is reparative calcification.






