27 April 2026
: Case report 
Gastric Sarcoidosis Masquerading as Gastroesophageal Reflux Disease: A Case of Diagnostic Uncertainty and Conservative Management
Challenging differential diagnosis, Rare disease
Olanrewaju Adeniran
ABCDEF 1*, Abdullahi Sulaiman BCDE 2, Megan Willard ABDEF 3
DOI: 10.12659/AJCR.951952
Am J Case Rep 2026; 27:e951952
Figure 5 Algorithm providing a step-by-step approach to the diagnosis and treatment of GERD in patients with gastric sarcoidosis. The algorithm includes confirmation of the diagnosis, assessment of GERD severity (mild, moderate, or severe), and selection of tailored treatment plans. Decision points indicate when to escalate therapy from conservative management with PPIs to immunosuppression or surgery, based on symptom response and evidence of active sarcoid inflammation. ACE – angiotensin-converting enzyme; AZA – azathioprine; CBC – complete blood count; CMP – comprehensive metabolic panel; GERD – gastroesophageal reflux disease; GI – gastrointestinal; LA – Los Angeles; MTX – methotrexate; PPI – proton pump inhibitor; TB – tuberculosis; TNF – tumor necrosis factor.