Figure 4 Clinical timeline of evaluation and managementSchematic timeline summarizing key diagnostic and therapeutic milestones in a late-preterm neonate with day-1-onset transfusion-dependent thrombocytopenia and intermittent normocytic anemia. NAIT was initially suspected and managed empirically with intravenous immunoglobulin while maternal anti–human platelet antigen (HPA) antibody testing was pending; subsequent negative results and absent platelet response reduced the likelihood of an alloimmune mechanism. Bone marrow examination demonstrated dysmegakaryopoiesis with reduced late megakaryocyte forms, followed by a trial of romiplostim without sustained platelet response. Trio-based sequencing with copy-number analysis identified a homozygous in-frame duplication in NFE2. The timeline also indicates the longitudinal course through January 2025, during which thrombocytopenia remained persistent with ongoing transfusion dependence.