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29 April 2026 : Case report  Japan

Hemolytic Glaucoma Following Intravitreal Aflibercept Injection for Age-Related Macular Degeneration: A Case Report

Diagnostic / therapeutic accidents

Hiroki Sano ORCID logo ABDEF 1*, Ryoji Yanai ORCID logo DE 2, Yoshinori Mitamura ORCID logo DE 2

DOI: 10.12659/AJCR.952247

Am J Case Rep 2026; 27:e952247

Figure 1 Imaging findings at baseline and before the tenth intravitreal aflibercept injection in neovascular age-related macular degeneration(A) Baseline color fundus photograph shows subretinal hemorrhage involving the fovea with surrounding yellowish deposits, consistent with active type 2 macular neovascularization; no peripheral retinal abnormalities were observed. The optic disc appeared large with a physiologic cup and no glaucomatous rim thinning. (B) Baseline horizontal optical coherence tomography (OCT) scan shows dome-shaped subretinal fluid and hemorrhage involving the fovea. (C) Baseline vertical OCT scan shows the vertical extent of the subretinal fluid and hemorrhage. (D) Color fundus photograph before the 10th intravitreal aflibercept injection shows complete resolution of subfoveal hemorrhage with residual gray-green subfoveal scarring/pigmentary change and no active hemorrhage or hard exudates. (E) Horizontal OCT scan before the tenth intravitreal aflibercept injection shows a dry macula with complete resolution of subretinal fluid and a mild subfoveal scarring. (F) Vertical OCT scan confirms the same finding, with no residual fluid or cystic change, indicating stable disease. (G) Ganglion cell–inner plexiform layer thickness map acquired during the treatment course demonstrates values within the normal range, with no evidence of glaucomatous structural loss. (H) Peripapillary retinal nerve fiber layer thickness map also shows a normal distribution across all clock-hour sectors, indicating the absence of pre-existing glaucomatous damage.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923