14 July 2026
: Case report 
Primary Small Cell Neuroendocrine Carcinoma of the Breast in a 75-Year-Old Woman With Aggressive Recurrence Despite Multimodal Therapy: A Case Report and Literature Review
Challenging differential diagnosis, Unusual setting of medical care, Rare coexistence of disease or pathology
Shefa Abdullah Alamoudi
ABCDEFG 1*, Hadeel Elwaheidi ABCDEFG 1, Hanan Albishi ABCD 2, Sarah Aldosari ABCDEFG 3, Asma M. Tulbah CD 4, Wafa Alkhayal ABCDEFG 5
DOI: 10.12659/AJCR.952443
Am J Case Rep 2026; 27:e952443
Figure 1 Breast ultrasound showing a single heterogeneous irregular hypoechoic mass (indicated by a red arrow) in the right breast, located at the 12 o’clock position, 1.5 cm from the nipple, and measuring 2.1×1.9×2.1 cm. The mass was associated with internal and peripheral vascularity with inner calcifications. It showed ductal extension with intraductal vascular components radiating and reaching the nipple, making it suspicious for nipple involvement. There was no axillary lymph node involvement.