14 July 2026
: Case report 
Primary Small Cell Neuroendocrine Carcinoma of the Breast in a 75-Year-Old Woman With Aggressive Recurrence Despite Multimodal Therapy: A Case Report and Literature Review
Challenging differential diagnosis, Unusual setting of medical care, Rare coexistence of disease or pathology
Shefa Abdullah Alamoudi
ABCDEFG 1*, Hadeel Elwaheidi ABCDEFG 1, Hanan Albishi ABCD 2, Sarah Aldosari ABCDEFG 3, Asma M. Tulbah CD 4, Wafa Alkhayal ABCDEFG 5
DOI: 10.12659/AJCR.952443
Am J Case Rep 2026; 27:e952443
Figure 3 Hematoxylin and eosin (H&E) staining of the right breast mastectomy specimen (original magnification ×200). Diffuse sheets and nests of densely packed small tumor cells with scant cytoplasm and hyperchromatic nuclei (indicated by red arrows) are seen within a fibrotic stroma. The morphological features are consistent with poorly differentiated neuroendocrine carcinoma, small cell type (Nottingham grade 3/3).