Primary Small Cell Neuroendocrine Carcinoma of the Breast in a 75-Year-Old Woman With Aggressive Recurrence Despite Multimodal Therapy: A Case Report and Literature Review

Shefa Abdullah Alamoudi; Hadeel Elwaheidi; Hanan Albishi; Sarah Aldosari; Asma M. Tulbah; Wafa Alkhayal

doi:10.12659/AJCR.952443

14 July 2026 : Case report Saudi Arabia

Primary Small Cell Neuroendocrine Carcinoma of the Breast in a 75-Year-Old Woman With Aggressive Recurrence Despite Multimodal Therapy: A Case Report and Literature Review

Challenging differential diagnosis, Unusual setting of medical care, Rare coexistence of disease or pathology

Shefa Abdullah Alamoudi

^{ABCDEFG 1*}, Hadeel Elwaheidi^{ABCDEFG 1}, Hanan Albishi^{ABCD 2}, Sarah Aldosari

^{ABCDEFG 3}, Asma M. Tulbah^{CD 4}, Wafa Alkhayal^{ABCDEFG 5}

DOI: 10.12659/AJCR.952443

Am J Case Rep 2026; 27:e952443

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Figure 5 Immunohistochemical staining for GATA-3 on the mastectomy specimen (original magnification ×200). Diffuse strong nuclear positivity (indicated by a red arrow) was observed in tumor cells, supporting a primary breast origin.

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Primary Small Cell Neuroendocrine Carcinoma of the Breast in a 75-Year-Old Woman With Aggressive Recurrence Despite Multimodal Therapy: A Case Report and Literature Review

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