Histoplasmosis-Associated Hemophagocytic Lymphohistiocytosis Presenting as Pyrexia of Unknown Origin With Splenic Masses

Nidhi Gupta; Kriti Yadav; Mythri Chittilla; Charly Almonte; Rahul Sampath

doi:10.12659/AJCR.952791

02 August 2026 : Case report USA

Histoplasmosis-Associated Hemophagocytic Lymphohistiocytosis Presenting as Pyrexia of Unknown Origin With Splenic Masses

Unusual clinical course, Challenging differential diagnosis, Unusual setting of medical care, Unexpected drug reaction, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Nidhi Gupta^{ABCDEF 1*}, Kriti Yadav^{CDF 1}, Mythri Chittilla^{DF 1}, Charly Almonte^{EF 1}, Rahul Sampath^{ABCDG 1}

DOI: 10.12659/AJCR.952791

Am J Case Rep 2026; 27:e952791

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Figure 2 Computes tomography scan showing resolution of splenic masses after treatment for histoplasmosis.

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Histoplasmosis-Associated Hemophagocytic Lymphohistiocytosis Presenting as Pyrexia of Unknown Origin With Splenic Masses

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