20 July 2026
: Case report 
Case Report: Primary Central Nervous System Lymphoma With “Wine Glass” Sign Presenting as Somnolence and Fatigue
Challenging differential diagnosis
RuPing Xu E 1, XingYong Chen AG 1*DOI: 10.12659/AJCR.952923
Am J Case Rep 2026; 27:e952923
Figure 4 Histopathologic examination. Microscopic examination revealed infiltration of brain tissue by tumor cells. The tumor cells are large in size, with eosinophilic cytoplasm. The nuclei of tumor cells are round or oval, with a thick nuclear membrane, prominent nucleolus, and coarse nuclear chromatin. The presence of mitotic figures was also frequently observed (>5 tumor cells per high power field of view).