24 July 2026
: Case report 
Adult-Onset Central Nervous System Embryonal Tumor With Neuronal Differentiation: A Diagnostic Challenge
Challenging differential diagnosis, Rare disease
Anh Quynh Pham BCDEF 1,2*, Tuyen Van Pham AC 3, Thong Minh Pham A 1,2DOI: 10.12659/AJCR.953049
Am J Case Rep 2026; 27:e953049
Figure 3 Histopathological findings demonstrated a highly cellular tumor composed of sheets and clusters of small round blue cells characterized by hyperchromatic nuclei, scant cytoplasm, and a high nuclear-to-cytoplasmic ratio, along with rosette-like structures (A). Immunohistochemical staining showed the absence of CD20 (B), cytokeratin (C), glial fibrillary acidic protein (D), Sal-like protein 4 (SALL4) (E), and synaptophysin (F).