Single-Dose Nivolumab as a Trigger of Myocarditis, Myositis, and Myasthenia Gravis Overlap Syndrome With Late Cardiac Death Despite Initial Recovery: A Case Report

Deepika Beereddy; Durga Naga Malleswara Rao Jonnalagadda; Shobha Mandal; Jieyu Zhang

doi:10.12659/AJCR.953173

14 July 2026 : Case report USA

Single-Dose Nivolumab as a Trigger of Myocarditis, Myositis, and Myasthenia Gravis Overlap Syndrome With Late Cardiac Death Despite Initial Recovery: A Case Report

Unusual or unexpected effect of treatment, Rare disease, Adverse events of drug therapy

Deepika Beereddy^{ABCDEF 1*}, Durga Naga Malleswara Rao Jonnalagadda^{ABCE 1}, Shobha Mandal^{CDE 2}, Jieyu Zhang^{B 1}

DOI: 10.12659/AJCR.953173

Am J Case Rep 2026; 27:e953173

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Figure 2 Apical 4-chamber view of transthoracic echocardiogram with Definity contrast (perflutren lipid microsphere) demonstrating preserved left ventricular ejection fraction (64%) in (A) end-diastole and (B) end-systole.

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Single-Dose Nivolumab as a Trigger of Myocarditis, Myositis, and Myasthenia Gravis Overlap Syndrome With Late Cardiac Death Despite Initial Recovery: A Case Report

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