06 May 2026
: Case report 
Splenic Marginal Zone Lymphoma as a Vascular-Appearing Mass in a Patient With Sustained Virologic Response to Hepatitis C Therapy
Challenging differential diagnosis, Rare disease
Xu Hao Isaac Tan ABCDEF 1*, Han Ning Yee
ABDE 2, Kah Wai Clarence Kwan ADE 3, Alvin Yong Hui Tan ADE 4, Shawn Kok ADE 1, Min On Tan ADE 1
DOI: 10.12659/AJCR.953179
Am J Case Rep 2026; 27:e953179
Figure 5 Morphological and immunohistochemical features of splenic marginal zone lymphoma. (A) A biphasic appearance is discernible from the splenic white pulps, showing expansion of pale marginal zones, associated with an inner, dark mantle zone; these findings are classical for splenic marginal zone lymphoma (H&E, 100×). (B, C) CD20 immunohistochemistry highlights confluent and interconnecting sheets of small lymphomatous B-cells [2× (B) and 20× (C)]. (D) The lesional marginal zone lymphocytes also co-express IgD (IHC, 20×). H&E – hematoxylin and eosin; IHC – immunohistochemistry.