15 July 2026
: Case report 
A 73-Year-Old Man With a Late Isolated Brain Metastasis of Clear Cell Renal Cell Carcinoma Following a Durable Complete Response to Lenvatinib‐Pembrolizumab, Resulting in Deferred Cytoreductive Nephrectomy
Unusual clinical course
Fumihiro Ito ABDEF 1*, Koki Kobayashi B 1, Gaku Hayashi B 1, Shunsuke Kamijo B 1, Takashi Fujita A 1DOI: 10.12659/AJCR.953192
Am J Case Rep 2026; 27:e953192
Figure 1 Baseline computed tomography showing clear cell renal cell carcinoma with an inferior vena cava tumor thrombus and pulmonary metastases. (A) Axial contrast-enhanced computed tomography (CT) image showing the right renal mass (arrow). (B) Coronal contrast-enhanced CT image showing a level II inferior vena cava (IVC) tumor thrombus (arrow). (C) Axial chest CT image showing multiple bilateral pulmonary metastases (arrows). These findings established metastatic renal cell carcinoma requiring initial systemic therapy.