15 July 2026
: Case report 
A 73-Year-Old Man With a Late Isolated Brain Metastasis of Clear Cell Renal Cell Carcinoma Following a Durable Complete Response to Lenvatinib‐Pembrolizumab, Resulting in Deferred Cytoreductive Nephrectomy
Unusual clinical course
Fumihiro Ito ABDEF 1*, Koki Kobayashi B 1, Gaku Hayashi B 1, Shunsuke Kamijo B 1, Takashi Fujita A 1DOI: 10.12659/AJCR.953192
Am J Case Rep 2026; 27:e953192
Figure 2 Radiological response after lenvatinib plus pembrolizumab and complete extracranial response after deferred cytoreductive nephrectomy. (A) Contrast-enhanced computed tomography (CT) after systemic therapy showing marked reduction of the right renal tumor (arrow). (B) Coronal CT image after systemic therapy showing shrinkage of the inferior vena cava (IVC) tumor thrombus (arrow). (C) Chest CT after systemic therapy showing near-complete resolution of pulmonary metastases (arrows). (D) Follow-up chest CT after deferred cytoreductive nephrectomy showing disappearance of pulmonary metastases, consistent with complete response (CR).