15 July 2026
: Case report 
A 73-Year-Old Man With a Late Isolated Brain Metastasis of Clear Cell Renal Cell Carcinoma Following a Durable Complete Response to Lenvatinib‐Pembrolizumab, Resulting in Deferred Cytoreductive Nephrectomy
Unusual clinical course
Fumihiro Ito ABDEF 1*, Koki Kobayashi B 1, Gaku Hayashi B 1, Shunsuke Kamijo B 1, Takashi Fujita A 1DOI: 10.12659/AJCR.953192
Am J Case Rep 2026; 27:e953192
Figure 4 Brain magnetic resonance imaging before and after stereotactic body radiotherapy for isolated brain metastasis. (A) Axial fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) showing a solitary hyperintense lesion in the left occipital lobe (arrow). Gadolinium contrast was not administered at diagnosis because of clinical considerations. (B) Follow-up axial FLAIR MRI after stereotactic radiotherapy (SRT) showing marked reduction in lesion size and good local control.