25 July 2026
: Case report 
A 46-Year-Old Man Presenting With Chest Pain Due to Apical Hypertrophic Cardiomyopathy (Yamaguchi Syndrome) Diagnosed by Multimodal Cardiac Imaging
Challenging differential diagnosis, Management of emergency care, Rare disease
Mauro de Deus Passos ABDEF 1,2*, Daniel Lopes Marques de Araújo ABDEF 3, Lucas de Ávila Mariano ABDEF 3, Dilson Palhares Ferreira ABDEF 1,2, Luciano Moreira Alves ABDEF 4,5, Simone Nascimento dos Santos ABDEF 6DOI: 10.12659/AJCR.953259
Am J Case Rep 2026; 27:e953259
Figure 1 Standard 12-lead electrocardiogram (ECG) on admission demonstrating signs of left ventricular hypertrophy and apical ischemiaThe 12-lead ECG shows significant ST-segment depression in leads I, aVL, and V5–V6, associated with tall R-waves from V2 to V6, and characteristic giant negative (inverted) T-waves with an amplitude exceeding 10 mm in the precordial leads V4 to V6. These findings are highly suggestive of apical hypertrophic cardiomyopathy (Yamaguchi syndrome). ECG, electrocardiogram.