A 46-Year-Old Man Presenting With Chest Pain Due to Apical Hypertrophic Cardiomyopathy (Yamaguchi Syndrome) Diagnosed by Multimodal Cardiac Imaging

Mauro de Deus Passos; Daniel Lopes Marques de Araújo; Lucas de Ávila Mariano; Dilson Palhares Ferreira; Luciano Moreira Alves; Simone Nascimento dos Santos

doi:10.12659/AJCR.953259

25 July 2026 : Case report Brazil

A 46-Year-Old Man Presenting With Chest Pain Due to Apical Hypertrophic Cardiomyopathy (Yamaguchi Syndrome) Diagnosed by Multimodal Cardiac Imaging

Challenging differential diagnosis, Management of emergency care, Rare disease

Mauro de Deus Passos^{ABDEF 1,2*}, Daniel Lopes Marques de Araújo^{ABDEF 3}, Lucas de Ávila Mariano^{ABDEF 3}, Dilson Palhares Ferreira^{ABDEF 1,2}, Luciano Moreira Alves^{ABDEF 4,5}, Simone Nascimento dos Santos^{ABDEF 6}

DOI: 10.12659/AJCR.953259

Am J Case Rep 2026; 27:e953259

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Figure 2 Two-dimensional transthoracic echocardiogram (TTE) assessing myocardial wall thicknessTransthoracic echocardiographic images in the parasternal long-axis and apical views showing increased diastolic wall thickness in the (A) left ventricular (LV) anteroseptal basal segment (15.3 mm), (B) LV apex segment (18.8 mm), (C) LV septal apical segment (20.4 mm), and (D) LV anterior apical segment (20.0 mm). The images demonstrate the characteristic “spade-like” configuration of the LV cavity during diastole. LV, left ventricular; TTE, transthoracic echocardiogram.

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A 46-Year-Old Man Presenting With Chest Pain Due to Apical Hypertrophic Cardiomyopathy (Yamaguchi Syndrome) Diagnosed by Multimodal Cardiac Imaging

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