A 46-Year-Old Man Presenting With Chest Pain Due to Apical Hypertrophic Cardiomyopathy (Yamaguchi Syndrome) Diagnosed by Multimodal Cardiac Imaging

Mauro de Deus Passos; Daniel Lopes Marques de Araújo; Lucas de Ávila Mariano; Dilson Palhares Ferreira; Luciano Moreira Alves; Simone Nascimento dos Santos

doi:10.12659/AJCR.953259

25 July 2026 : Case report Brazil

A 46-Year-Old Man Presenting With Chest Pain Due to Apical Hypertrophic Cardiomyopathy (Yamaguchi Syndrome) Diagnosed by Multimodal Cardiac Imaging

Challenging differential diagnosis, Management of emergency care, Rare disease

Mauro de Deus Passos^{ABDEF 1,2*}, Daniel Lopes Marques de Araújo^{ABDEF 3}, Lucas de Ávila Mariano^{ABDEF 3}, Dilson Palhares Ferreira^{ABDEF 1,2}, Luciano Moreira Alves^{ABDEF 4,5}, Simone Nascimento dos Santos^{ABDEF 6}

DOI: 10.12659/AJCR.953259

Am J Case Rep 2026; 27:e953259

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Figure 3 Two-dimensional speckle-tracking echocardiography showing global longitudinal strain (GLS) analysisThe bull’s-eye plot represents a diffusely reduced longitudinal strain, most pronounced in the apical segments (represented by the lighter colors in the center of the plot), with an average GLS value of −14.3%. This pattern indicates regional myocardial dysfunction despite a preserved ejection fraction. GLS, global longitudinal strain.

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A 46-Year-Old Man Presenting With Chest Pain Due to Apical Hypertrophic Cardiomyopathy (Yamaguchi Syndrome) Diagnosed by Multimodal Cardiac Imaging

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