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09 July 2026 : Case report  Japan

Multidisciplinary Rehabilitation for Severe Respiratory Failure Due to Dasatinib-Induced Pulmonary Toxicity: A Case Report

Unusual clinical course, Unusual or unexpected effect of treatment, Adverse events of drug therapy

Kohei Nozaki ORCID logo ABDEFG 1*, Nobuaki Hamazaki ORCID logo ABDEF 1, Yosuke Takeshita ABD 2, Tomotaka Koike BDE 3, Shuken Kobayashi ABE 1, Ayako Ueta BD 1, Masayuki Arai BDE 4, Takahiro Suzuki BDE 2

DOI: 10.12659/AJCR.953380

Am J Case Rep 2026; 27:e953380

Figure 2 Clinical course. PaCO2 decreased rapidly upon initiation of mechanical ventilation, but high levels persisted, and peak airway pressure could not be reduced. The MRC score was maintained at 48 or higher, and although the Barthel Index was initially 0, it improved throughout the rehabilitation program and eventually achieved 100. Day 30: The mechanical ventilator was changed to a home mechanical ventilator. The patient and her family started practicing how to use it. Day 48: Exercise therapy began in the rehabilitation room while on a mechanical ventilator. Day 57: During the day, the patient was successfully weaned off the mechanical ventilator and was able to spend time wearing a 1 L O2 tracheal mask. At night, the patient continued to use the mechanical ventilator. Day 73: The Barthel index achieved a score of 100 points. Day 87: A multidisciplinary conference was held with hospital staff and community medical staff to explain and share information with the patient, her family, and specialists providing home care about precautions for living at home and responding to emergencies. Day 105: The patient was discharged from the hospital and returned home. During the day, the patient received 1 L of oxygen, and at night, the patient used a mechanical ventilator. MRC, medical research council; PaCO2, partial pressure of arterial carbon dioxide; PIP, peak inspiratory pressure.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923