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09 July 2026 : Case report  Japan

Multidisciplinary Rehabilitation for Severe Respiratory Failure Due to Dasatinib-Induced Pulmonary Toxicity: A Case Report

Unusual clinical course, Unusual or unexpected effect of treatment, Adverse events of drug therapy

Kohei Nozaki ORCID logo ABDEFG 1*, Nobuaki Hamazaki ORCID logo ABDEF 1, Yosuke Takeshita ABD 2, Tomotaka Koike BDE 3, Shuken Kobayashi ABE 1, Ayako Ueta BD 1, Masayuki Arai BDE 4, Takahiro Suzuki BDE 2

DOI: 10.12659/AJCR.953380

Am J Case Rep 2026; 27:e953380

Figure 3 Changes in each parameter pre-, during, and post-rehabilitation. No significant changes in blood pressure were observed during any of the rehabilitation stages. Although heart rate and respiratory rate increased during the rehabilitation program, no adverse events occurred. SpO2 showed a slight decrease during in-bed exercises and transfers to a wheelchair, but symptoms were minimal and the situation was deemed acceptable. EtCO2 remained elevated until Day 6 regardless of rehabilitation but decreased from Day 7. Changes related to the rehabilitation program were largely not observed. EtCO2 ended daytime monitoring after day 49. The values shown are means. BP, blood pressure; bpm, beats per minute; EtCO2, end-tidal carbon dioxide tension; HR, heart rate; RR, respiratory rate; SpO2, saturation of percutaneous oxygen.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923