07 September 2026
: Case report 
Refractory Stasis Dermatitis Due to Chronic Venous Insufficiency With Psychosocial Worsening in 2 Septuagenarian Patients Treated With Hyaluronic Acid–Succinic Acid Intradermotherapy
Unusual clinical course, Unusual setting of medical care
Qiaofeng Zhao BCDEFG 1, Marjorie P. Zambrano
DEF 2, Sofia Brito DEF 3,4, Bum-ho Bin DEF 3,4, Yuping Ran DEF 5,6, Alberto Leguina-Ruzzi ABCDEF 7,8*
DOI: 10.12659/AJCR.953520
Am J Case Rep 2026; 27:e953520
Figure 2 Changes in neurosensory symptoms during treatment with HMWNCHA and SA. Patient-reported symptom severity during treatment in Cases 1 and 2. Pain (A), burning sensation (B), pruritus (C), and tingling (D) were evaluated using the NRS, with 0 representing no symptoms and 10 representing the worst imaginable symptoms. Scores were recorded at baseline before treatment initiation, after the first treatment session, and after the second treatment session. Both patients demonstrated progressive improvement in all evaluated neurosensory symptoms throughout treatment. NRS, Numerical Rating Scale; HMWNCHA, high-molecular-weight non-crosslinked hyaluronic acid; SA, succinic acid.