Figure 3 Clinical improvement of unilateral stasis dermatitis following intradermotherapy with HMWNCHA and SA in Case 2. Serial clinical photographs of a 75-year-old female patient with unilateral stasis dermatitis of the left ankle treated with intradermal microinjections of HMWNCHA combined with SA. (A) Baseline presentation showing an erythematous lesion associated with xerosis and skin damage. (B) Clinical appearance 1 month after the first treatment session, demonstrating reduction in erythema and improvement in skin hydration. (C) Clinical appearance 1 month after the second treatment session (2 months after treatment initiation), showing marked reduction in lesion size and progressive skin regeneration. (D) Six-month follow-up after the second treatment session (8 months after treatment initiation), demonstrating near-complete resolution of the lesion and maintenance of clinical remission. HMWNCHA, high-molecular-weight non-crosslinked hyaluronic acid; SA, succinic acid.