Co-Occurring EGFR L858R Mutation and HER2 Amplification in NSCLC Identified by Stepwise Molecular Profiling

Rabiga Kadyrbayeva; Dilyara Kaidarova; Aisha Moldasheva; Kaldygul Kabakovna Smagulova; Innara Turkpenova; Madina Orazgalieva; Saniya Omirkhanovna Ossikbayeva; Elvira Satbayeva; Valeriy Makarov

doi:10.12659/AJCR.953829

02 September 2026 : Case report Kazakhstan

Co-Occurring EGFR L858R Mutation and HER2 Amplification in NSCLC Identified by Stepwise Molecular Profiling

Rare coexistence of disease or pathology

Rabiga Kadyrbayeva^{ABCDEFG 1,2*}, Dilyara Kaidarova^{ADG 2}, Aisha Moldasheva

^{FG 1}, Kaldygul Kabakovna Smagulova^{BF 1}, Innara Turkpenova^{CD 1}, Madina Orazgalieva^{DE 1}, Saniya Omirkhanovna Ossikbayeva^{D 1}, Elvira Satbayeva^{DE 3}, Valeriy Makarov^{CD 4}

DOI: 10.12659/AJCR.953829

Am J Case Rep 2026; 27:e953829

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Figure 1 Initial chest computed tomography scan showing a mixed ground-glass and solid lesion in the right upper lobe.

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Co-Occurring EGFR L858R Mutation and HER2 Amplification in NSCLC Identified by Stepwise Molecular Profiling

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