02 September 2026
: Case report 
Co-Occurring EGFR L858R Mutation and HER2 Amplification in NSCLC Identified by Stepwise Molecular Profiling
Rare coexistence of disease or pathology
Rabiga Kadyrbayeva ABCDEFG 1,2*, Dilyara Kaidarova ADG 2, Aisha Moldasheva
FG 1, Kaldygul Kabakovna Smagulova BF 1, Innara Turkpenova CD 1, Madina Orazgalieva DE 1, Saniya Omirkhanovna Ossikbayeva D 1, Elvira Satbayeva DE 3, Valeriy Makarov CD 4
DOI: 10.12659/AJCR.953829
Am J Case Rep 2026; 27:e953829
Figure 3 Timeline of clinical course, including key diagnostic milestones, molecular findings (polymerase chain reaction, fluorescent in situ hybridization, and next-generation sequencing), and treatment interventions.