Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

09 March 2001

The Role of Non-Myeloablative Conditioning in Allowing Engraftment of Allogeneic Hematopoietic Cells for Correction of Genetic Disorders and for Immunotherapy of Leukemia

Abdulnaser Awedan

Ann Transplant 2001; 6(1): 9-13 :: ID: 497564

Abstract

Transplant lite or allogeneic bone marrow transplantation after non-myeloablative conditioning is a novel approach to the treatment of hematological malignancies and genetic diseases, which hinges on the replacement of myeloablative conditioning regimen prior to transplant (i.e., destruction of the entire hematopoietic system of the recipient) by immune ablation (i.e. destruction of only immune system rejecting the transplant). Infused hematopoietic cells have to engraft in the presence of host hematopoietic cells that survive conditioning. The net result is the appearance of the so called mixed chimerism, which indicates the presence of a variable number of donor cells among cells of host origin. Further immunomodulation after transplantation isused to increase engraftment. decrease graft versus host disease and to maintain graft versus disease effect. This strategy permits allogeneic transplantation to be used in older patients and those with comorbidities that are unable to tolerate conventional high-dose preparative regimens. In consequence, it would increase the range of disorders to be treated with bone marrow transplantation. Additionally, this could be supplemented by the transfer of immune cells of bone marrow transplant donor to induce graft-versus leukemia effect. Different non-myeloablative conditioning regimens have been proposed: one regimen is using low dose TBI [200 cGy] and several others are based on purine analogues. The aim of this review is to describe this new allogeneic approach to the treatment of hematological malignancies as well as genetic disorders.

Keywords: allogeneic bone marrow transplantation, anti-T cell agent, low dose (200cGy) radiation

Add Comment 0 Comments

In Press

08 Mar 2024 : Original article  

Association of Coronary Calcium Score on Cardiac PET During Pre-Kidney Transplant Assessment with Persisten...

Ann Transplant In Press; DOI: 10.12659/AOT.943532  

14 Mar 2024 : Original article  

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung Transplant Period: A Cohort Study

Ann Transplant In Press; DOI: 10.12659/AOT.943652  

14 Mar 2024 : Case report  

Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo ...

Ann Transplant In Press; DOI: 10.12659/AOT.942358  

15 Mar 2024 : Review article  

Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...

Ann Transplant In Press; DOI: 10.12659/AOT.941185  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358