07 October 2008
Am J Case Rep 2008; 9:408-410 :: ID: 869421
Background: Malignant mesothelioma is an aggressive tumor of serosal surfaces, such as the pleura and the peritoneum. Local invasion is common involving the adjacent organs. Distant metastasis is rare.
Case Report: We present an interesting case report of a 60-year-old lady with malignant pleural mesothelioma with vertebral collapse, which initially thought to be a metastasis turned out to be vertebral infarction due to compromise in blood supply to the vertebra as a result of contiguous spread of the mesothelioma. This lady presented with low back ache, nontraumatic in origin without neurological symptoms. CT and MR scan revealed significant changes in T12 vertebra with vertebral collapse. Surgical intervention was necessary to obtain pain relief and to get bone sample for biopsy to confirm diagnosis. Histopathological examination of bone specimens revealed samples of bone containing normal haematopoietic tissue together with fragments of partly degenerative necrotic tissue. No morphologically or immunohistochemically viable tumour was identified.
Conclusions: Analysing the various possible causes for vertebral collapse from literature, CT/MRI scan and biopsy report, we identified that the pleural mesothelioma had spread in contiguity, encircled the spine near the thoraco-lumbar junction and interfered with the vascular supply of the vertebral body leading to collapse of the T12 vertebra.
Keywords: malignant mesothelioma, Back Pain, vertebral collapse , spinal stabilisation
22 September 2022 : Case reportRare Case of Persistently Depressed T Lymphocyte Subsets After SARS-CoV-2 Infection
Am J Case Rep In Press; DOI: 10.12659/AJCR.937760
22 September 2022 : Case reportCentral Retinal Vein Occlusion After Discontinuation of Rivaroxaban Therapy in a Young Patient with COVID-1...
Am J Case Rep In Press; DOI: 10.12659/AJCR.937739
19 September 2022 : Case reportInhaled Nitric Oxide in Acute Severe Pulmonary Hypertension and Severe Acute Respiratory Distress Syndrome ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.937147
27 Sep 2022 : Case reportCompound Heterozygote Mutation in the SMPD1 Gene Leading to Nieman-Pick Disease Type A
Am J Case Rep In Press; DOI: 10.12659/AJCR.937220
26 Sep 2022 : Case reportAn Infant Presenting with Interstitial Lung Disease Diagnosed Later as Hunter Syndrome: A Case Report
Am J Case Rep In Press; DOI: 10.12659/AJCR.937527
26 Sep 2022 : Case reportAcute Intermittent Porphyria: Complete Phenotype in a Patient with p.Arg173Trp Variant in Thailand
Am J Case Rep In Press; DOI: 10.12659/AJCR.937695
Most Viewed Current Articles
13 Jul 2022 : Case reportWhistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound
Am J Case Rep 2022; 23:e936441
23 Feb 2022 : Case reportPenile Necrosis Associated with Local Intravenous Injection of Cocaine
Am J Case Rep 2022; 23:e935250
06 Dec 2021 : Case reportLipedema Can Be Treated Non-Surgically: A Report of 5 Cases
Am J Case Rep 2021; 22:e934406