Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

22 September 2010

Atypical primary Burkitt lymphoma of the thyroid gland: A practical approach for differential diagnosis and management

Roberta Claudi, Patrizia Viola, Roberto Cotellese, Domenico Angelucci

Am J Case Rep 2010; 11:169-173 :: ID: 881159

Abstract

Background: Primary thyroid lymphomas are rare diseases that continue to produce diagnostic and therapeutic dilemmas. Among these, Diffuse Large B-Cell Lymphoma (DLBCL) represents the more common subtype while Burkitt lymphoma (BL) is unusual. Distinguishing between BL and DLBCL is critical as the two disease require different therapeutic management. Diagnostic accuracy is therefore essential to obtain patient safety.
Here, we described the second case of Burkitt Lymphoma of the thyroid gland reported in the English literature, investigate the differential diagnosis and explore the diagnostic approach that might be used when neoplasia with morphological features intermediate between BL and DLBCL happens on pathologist’s practice.
Case Report: A 56-year-old women presented to our attention for the evaluation of a rapidly growing neck mass causing compressive symptoms. Ultrasound examination demonstrated two hypoechogenic nodules within a diffusely enlarged thyroid gland. Histological analysis showed cells resembling DLBCL, as well as starry sky pattern and immunohistochemical pattern suggestive of BL. The final diagnosis of BL was confirmed by FISH analysis that demonstrated c-myc-IgH rearrangement with t(8;14) translocation.
Conclusions: This study demonstrates that no single parameter alone (such as morphology, genetics analysis or immunophenotyping) can be used as gold standard for the diagnosis of BL, but a combination of several diagnostic techniques is necessary for an optimal practical approach. Since treatment regimens for BL and DLBCL differ significantly, we believe that our study should be useful to suggest the correct diagnostic algorithm to be used when a case of BL, with unusual localization and ambiguous morphological features, is encountered in routine setting.

Keywords: atypical Burkitt lymphoma, lymphoma of the thyroid gland, diagnosis of atypical BL

Comments

SARS-CoV-2/COVID-19

16 June 2022 : Case report  Ecuador

Multidrug-Resistant Klebsiella pneumoniae in a Patient with SARS-Cov-2 Pneumonia in an Intensive Care Unit ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.936498  

13 June 2022 : Case report  Japan

Stenotrophomonas maltophilia Infection Associated with COVID-19: A Case Series and Literature Review

Am J Case Rep In Press; DOI: 10.12659/AJCR.936889  

13 June 2022 : Case report  Saudi Arabia

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

Am J Case Rep In Press; DOI: 10.12659/AJCR.936128  

03 June 2022 : Case report  Japan

Clinical Outcomes of Sotrovimab Treatment in 10 High-Risk Patients with Mild COVID-19: A Case Series

Am J Case Rep In Press; DOI: 10.12659/AJCR.936832  

In Press

24 Jun 2022 : Case report  USA

A 24-Year-Old Man Presenting with Lung Metastases from a Primary Retroperitoneal Extragonadal Choriocarcinoma

Am J Case Rep In Press; DOI: 10.12659/AJCR.936288  

24 Jun 2022 : Case report  Romania

Odontogenic Keratocyst: The Dos and Don’ts in a Clinical Case Scenario

Am J Case Rep In Press; DOI: 10.12659/AJCR.936641  

24 Jun 2022 : Case report  Saudi Arabia

Management of Patients with Alagille Syndrome Undergoing Living Donor Liver Transplantation: A Report of 2 ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.936513  

22 Jun 2022 : Case report  USA

A Case of Lymphomatoid Granulomatosis in a Lymph Node with Unique Clinical and Histopathologic Features

Am J Case Rep In Press; DOI: 10.12659/AJCR.936862  

Most Viewed Current Articles

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

17 Feb 2022 : Case report  Oman

Myocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...

DOI :10.12659/AJCR.934399

Am J Case Rep 2022; 23:e934399

06 Dec 2021 : Case report  Brazil

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

09 Feb 2022 : Case report  Saudi Arabia

Extensive Cerebral Venous Sinus Thrombosis (CVST) After the First Dose of Pfizer-BioNTech BNT162b2 mRNA COV...

DOI :10.12659/AJCR.934744

Am J Case Rep 2022; 23:e934744

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923