Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

22 September 2010

Atypical primary Burkitt lymphoma of the thyroid gland: A practical approach for differential diagnosis and management

Roberta Claudi, Patrizia Viola, Roberto Cotellese, Domenico Angelucci

Am J Case Rep 2010; 11:169-173 :: ID: 881159


Background: Primary thyroid lymphomas are rare diseases that continue to produce diagnostic and therapeutic dilemmas. Among these, Diffuse Large B-Cell Lymphoma (DLBCL) represents the more common subtype while Burkitt lymphoma (BL) is unusual. Distinguishing between BL and DLBCL is critical as the two disease require different therapeutic management. Diagnostic accuracy is therefore essential to obtain patient safety.
Here, we described the second case of Burkitt Lymphoma of the thyroid gland reported in the English literature, investigate the differential diagnosis and explore the diagnostic approach that might be used when neoplasia with morphological features intermediate between BL and DLBCL happens on pathologist’s practice.
Case Report: A 56-year-old women presented to our attention for the evaluation of a rapidly growing neck mass causing compressive symptoms. Ultrasound examination demonstrated two hypoechogenic nodules within a diffusely enlarged thyroid gland. Histological analysis showed cells resembling DLBCL, as well as starry sky pattern and immunohistochemical pattern suggestive of BL. The final diagnosis of BL was confirmed by FISH analysis that demonstrated c-myc-IgH rearrangement with t(8;14) translocation.
Conclusions: This study demonstrates that no single parameter alone (such as morphology, genetics analysis or immunophenotyping) can be used as gold standard for the diagnosis of BL, but a combination of several diagnostic techniques is necessary for an optimal practical approach. Since treatment regimens for BL and DLBCL differ significantly, we believe that our study should be useful to suggest the correct diagnostic algorithm to be used when a case of BL, with unusual localization and ambiguous morphological features, is encountered in routine setting.

Keywords: atypical Burkitt lymphoma, lymphoma of the thyroid gland, diagnosis of atypical BL

Add Comment 0 Comments

641 2

In Press

25 May 2023 : Case report  Latvia

Neuroendocrine Carcinoma of the Extrahepatic Bile Ducts: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.939239  

24 May 2023 : Case report  South Africa

An Initially Missed Diagnosis of Venous Thromboembolic Phenomenon in Adult-Onset Still’s Disease: A Case Re...

Am J Case Rep In Press; DOI: 10.12659/AJCR.939520  

24 May 2023 : Case report  Italy

Successful Surgical Removal of a Giant Serous Ovarian Cyst in a 52-Year-Old Woman with Presurgical Body Mas...

Am J Case Rep In Press; DOI: 10.12659/AJCR.939697  

23 May 2023 : Case report  Japan

Successful Noninvasive Respiratory Management of an Infant with Bilateral Choanal Atresia and a Supernumera...

Am J Case Rep In Press; DOI: 10.12659/AJCR.939642  

Most Viewed Current Articles

06 Dec 2021 : Case report  Brazil

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

13 Jul 2022 : Case report  USA

Whistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound

DOI :10.12659/AJCR.936441

Am J Case Rep 2022; 23:e936441

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

07 Dec 2021 : Case report  USA

Edwardsiella tarda: A Classic Presentation of a Rare Fatal Infection, with Possible New Background Risk Fac...

DOI :10.12659/AJCR.934347

Am J Case Rep 2021; 22:e934347

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923