06 June 2012
Am J Case Rep 2012; 13:102-105
Background: Amyloidosis is a systemic disorder that results from the tissue deposition of various proteins with distinctive morphological characteristics. Conjunctival amyloidosis is a rare variant which is generally localized and not associated with systemic involvement.
Case Report: We present here a case of 47-year-old female patient with right eyelid swelling that progressed over a 12 year period and eventually underwent surgery with pathology showing AL conjunctival amyloidosis. Unlike in most other reported cases of localized amyloidosis, she was noted to have amyloid deposition in the bone marrow and gastrointestinal tract upon extensive evaluation without any evidence of underlying plasma cell dyscrasia. She has been on observation without evidence of systemic progression or recurrence of conjunctival amyloid.
Conclusions: Although it initially appeared that our case represented an isolated form of AL (kappa)-type conjunctival amyloidosis, systemic evaluation revealed trace amount of amyloid in the bone marrow and GI tract. It is feasible that upon very close scrutiny patients with seemingly localized AL amyloidosis may have trace amounts of amyloid involving other organs and based on experience from this single patient we believe that it is safe to observe such patients closely rather than pursue systemic therapy.
Keywords: Amyloidosis, Multiple Myeloma, Congo Red
11 August 2022 : Case reportA 32-Year-Old Man with Persistent Olfactory Dysfunction Following COVID-19 Whose Recovery Was Evaluated by ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.936496
09 August 2022 : Case reportA Case of Segmental Arterial Mediolysis of Multiple Visceral Arteries Following Anti-COVID-19 Vaccination: ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.937505
29 July 2022 : Case reportPosterior Myocardial Infarction in a 45-Year-Old Javanese Woman with a 1-Month History of COVID-19-Related ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.937105
16 Aug 2022 : Case reportCoronary Artery Stent Dislodgement and Loss in the Bloodstream: A Case Report and Management Options
Am J Case Rep In Press; DOI: 10.12659/AJCR.937598
16 Aug 2022 : Case reportA Pituitary Abscess Caused by Morganella morganii: A Case Report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936743
16 Aug 2022 : Case reportStapedotomy in Congenital Stapes Ankylosis with Mobile Footplate: A Case Report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936466
Most Viewed Current Articles
13 Jul 2022 : Case reportWhistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound
Am J Case Rep 2022; 23:e936441
23 Feb 2022 : Case reportPenile Necrosis Associated with Local Intravenous Injection of Cocaine
Am J Case Rep 2022; 23:e935250
06 Dec 2021 : Case reportLipedema Can Be Treated Non-Surgically: A Report of 5 Cases
Am J Case Rep 2021; 22:e934406