10 September 2012
A case of synchronous double primary breast carcinoma and osteosarcoma: Mismatch repair genes mutations as a possible cause for multiple early onset malignant tumors
Hytham Ahmed, Asmaa Salama, Salem Eid Salem, Abeer BahnassyDOI: 10.12659/AJCR.883382
Am J Case Rep 2012; 13:218-223
Abstract
Background: Simultaneous or consequent development of multiple solid tumors might be faced in some patients, especially the young. These tumors might be related to certain hereditary cancer syndromes or certain genetic predispositions.
Case Report: We present the case of a 19-year-old woman with metastatic breast cancer to the contralateral axillary lymph node, associated with simultaneous osteosarcoma of the left lower femur. As she did not fit into any of the familial cancer syndromes, genetic predisposition was suspected. We detected MLH1 and MSH2 promotor methylation (PM), microsatellite instability (MSI), and different mutational events in both tumors. BRCA1 gene mutations were detected in the breast tumor, with reduced mRNA expression of BRCA1&2. ERCC1, MLH1 and MSH2, especially in OS, and RRM1 was overexpressed in both tumors.
Conclusions: Aberrations in MMR genes could explain simultaneous or consequent development of multiple solid tumors, especially in a young patient. We recommend detecting these defects, close follow-up for those patients, and genetic counseling for their family members. Further studies in a larger population are essential to support our results.
Keywords: Breast Cancer, double primary, Mismatch Repair Genes
In Press
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.947344
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.946589
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.947316
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.947693
Most Viewed Current Articles
21 Jun 2024 : Case report
100,250
DOI :10.12659/AJCR.944371
Am J Case Rep 2024; 25:e944371
07 Mar 2024 : Case report
53,680
DOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
20 Nov 2023 : Case report
36,071
DOI :10.12659/AJCR.941424
Am J Case Rep 2023; 24:e941424
07 Jul 2023 : Case report
24,897
DOI :10.12659/AJCR.940200
Am J Case Rep 2023; 24:e940200