09 February 2013
An 80-year-old female with double positive disease: Case report and brief review of literature
Tarek Almouradi, Peter Hart, Talia Muram-ZborovskiDOI: 10.12659/AJCR.883761
Am J Case Rep 2013; 14:30-33
Abstract
Background: Goodpasture’s syndrome is a triad of alveolar hemorrhage, Glomerulonephritis and circulating anti Glomerular basement membrane antibodies, 25% of cases test positive for ANCA antibodies, this association is known as Double positive disease. This article describes a rare presentation of this entity and reviews available literature.
Case Report: 80 year old female presented with hemoptysis and renal failure, she tested positive for both p ANCA and anti glomerular basement membrane antibodies, and despite aggressive medical treatment, she suffered a frustrating outcome.
Conclusions: Double positive disease accounts for 25% of cases of Goodpasture’s syndrome, a suggested Pathophysiology of this association is the renal involvement in ANCA Vasculitis leading to the exposure of antigens from the basement membrane and the formation of antibodies.
This entity is believed to carry better prognosis when compared to isolated anti glomerular basement membrane disease.
Keywords: Anti-Glomerular Basement Membrane Disease, p-ANCA, Pulmonary renal syndrome, double positive disease
In Press
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.949194
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.948731
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.947386
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.948268
Most Viewed Current Articles
21 Jun 2024 : Case report
101,937
DOI :10.12659/AJCR.944371
Am J Case Rep 2024; 25:e944371
07 Mar 2024 : Case report
54,506
DOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
20 Nov 2023 : Case report
38,182
DOI :10.12659/AJCR.941424
Am J Case Rep 2023; 24:e941424
07 Jul 2023 : Case report
25,994
DOI :10.12659/AJCR.940200
Am J Case Rep 2023; 24:e940200