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07 August 2013 : Case report  Australia

Renal cell carcinoma in a setting of chronic lithium toxicity

Challenging differential diagnosis, Rare disease, Adverse events of drug therapy , Educational Purpose (only if useful for a systematic review or synthesis)

Ibrahim ZardawiABCDEF, Santoshi NagonkarBCD, Purvish PatelBCD

DOI: 10.12659/AJCR.889398

Am J Case Rep 2013; 14:300-303

Abstract

Background: Lithium salts are widely used in the treatment of affective disorders of the bipolar type. Lithium is a nephrotoxic substance which can cause both acute and chronic renal disease, including cyst formation. Cysts appear to predispose the kidney to renal cell carcinoma.
Case Report: A case of renal cell carcinoma in a background of acquired cystic disease due to chronic lithium toxicity is described.
Conclusions: Kidneys with multiple cysts are at risk of renal cell carcinoma. Although it is difficult to determine if long term Lithium use renal cell carcinoma, patients leads to the development of on long-term lithium therapy should undergo regular renal function and imaging tests.

Keywords: Carcinoma, Renal Cell, renal cysts, Anti-Inflammatory Agents, Non-Steroidal, Lithium Chloride, Kidney Neoplasms

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923