14 April 2014
: Case report
The potent synergistic effects of the combination of liraglutide and canagliflozin on glycemic control and weight loss
Unusual or unexpected effect of treatment, Unexpected drug reaction
David S.H. BellABCDEFDOI: 10.12659/AJCR.890626
Am J Case Rep 2014; 15:152-154
Abstract
BACKGROUND: Studies of the efficacy of the combination of the incretin mimetic liraglutide and the SGLT2 inhibitor canagliflozin or indeed studies of the combination of any incretin mimetic with an SGLT2 inhibitor have neither been performed nor published. Pharmacologically, the combination of an incretin-mimetic and an SGLT2-receptor blocker should result in a more significant weight loss and a greater reduction in postprandial glucose and HbA1c.
CASE REPORT: An insulin-dependent type 2 diabetic patient with multiple diabetic complications was placed on the combination of liraglutide and canagliflozin and 4 weeks later was able to discontinue insulin. In addition, in spite of discontinuing insulin, his HbA1c dropped from 7.0% to 6.8%, and he had reductions in body (weight from 247 to 218 lbs), BMI (from 34 to 29.5 Kg/m2), waist circumference (from 47 to 44 ½ inches), and neck circumference (from 19 ½ to 18 ¼ inches).
CONCLUSIONS: The combination of an SGLT2 inhibitor and an incretin mimetic/analog results in improved glycemic control accompanied by significant weight loss. This combination needs to be studied in a prospective randomized trial because the effect of each of the components of this combination is synergistically magnified by the addition of the partner drug.
Keywords: Diabetes Mellitus, Type 2, Incretins, Sodium-Glucose Transporter 2
831 3
In Press
20 Sep 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.939071
18 Sep 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.940628
18 Sep 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.940792
18 Sep 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.941004
Most Viewed Current Articles
06 Dec 2021 : Case report
DOI :10.12659/AJCR.934406
Am J Case Rep 2021; 22:e934406
07 Dec 2021 : Case report
DOI :10.12659/AJCR.934347
Am J Case Rep 2021; 22:e934347
13 Jul 2022 : Case report
DOI :10.12659/AJCR.936441
Am J Case Rep 2022; 23:e936441
23 Feb 2022 : Case report
DOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250