14 April 2014 : Case report
The potent synergistic effects of the combination of liraglutide and canagliflozin on glycemic control and weight loss
Unusual or unexpected effect of treatment, Unexpected drug reactionDavid S.H. BellABCDEF
Am J Case Rep 2014; 15:152-154
BACKGROUND: Studies of the efficacy of the combination of the incretin mimetic liraglutide and the SGLT2 inhibitor canagliflozin or indeed studies of the combination of any incretin mimetic with an SGLT2 inhibitor have neither been performed nor published. Pharmacologically, the combination of an incretin-mimetic and an SGLT2-receptor blocker should result in a more significant weight loss and a greater reduction in postprandial glucose and HbA1c.
CASE REPORT: An insulin-dependent type 2 diabetic patient with multiple diabetic complications was placed on the combination of liraglutide and canagliflozin and 4 weeks later was able to discontinue insulin. In addition, in spite of discontinuing insulin, his HbA1c dropped from 7.0% to 6.8%, and he had reductions in body (weight from 247 to 218 lbs), BMI (from 34 to 29.5 Kg/m2), waist circumference (from 47 to 44 ½ inches), and neck circumference (from 19 ½ to 18 ¼ inches).
CONCLUSIONS: The combination of an SGLT2 inhibitor and an incretin mimetic/analog results in improved glycemic control accompanied by significant weight loss. This combination needs to be studied in a prospective randomized trial because the effect of each of the components of this combination is synergistically magnified by the addition of the partner drug.
Keywords: Diabetes Mellitus, Type 2, Incretins, Sodium-Glucose Transporter 2
20 Sep 2023 : Case reportA Red, Swollen, and Warm Foot in a Kidney–Pancreas-Transplanted Type 1 Diabetic Patient: Is It Always Charc...
Am J Case Rep In Press; DOI: 10.12659/AJCR.939071
18 Sep 2023 : Case reportLife-Threatening Aortic Dissection during Pregnancy: A Case Report of Undiagnosed FBN1-Related Marfan Syndr...
Am J Case Rep In Press; DOI: 10.12659/AJCR.940628
18 Sep 2023 : Case reportA Lethal Combination: Legionnaires’ Disease Complicated by Rhabdomyolysis, Acute Kidney Injury, and Non-Occ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.940792
Most Viewed Current Articles
06 Dec 2021 : Case reportLipedema Can Be Treated Non-Surgically: A Report of 5 Cases
Am J Case Rep 2021; 22:e934406
07 Dec 2021 : Case reportEdwardsiella tarda: A Classic Presentation of a Rare Fatal Infection, with Possible New Background Risk Fac...
Am J Case Rep 2021; 22:e934347
13 Jul 2022 : Case reportWhistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound
Am J Case Rep 2022; 23:e936441