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31 October 2014 : Case report  Turkey

Terlipressin-Induced Ischemic Skin Necrosis: A Rare Association

Adverse events of drug therapy , Educational Purpose (only if useful for a systematic review or synthesis)

Banu Demet Ozel CoskunABE, Ahmet KaramanBF, Hasan GorkemBD, Irfan BuğdayDF, Orhan Kursad PoyrazoğluBF, Fatma SenelG

DOI: 10.12659/AJCR.891084

Am J Case Rep 2014; 15:476-479

Abstract

BACKGROUND: Terlipressin is a synthetic vasopressin analogue that is used in the treatment of bleeding esophageal varices and hepatorenal syndrome in patients with cirrhosis. Serious ischemic adverse events, such as skin necrosis involving the extremities, scrotum, trunk, and abdominal skin, are rarely observed. In the literature to date, 20 cases that developed ischemic skin necrosis due to terlipressin usage have been reported.

CASE REPORT: We report a patient with extensive skin necrosis on the infusion site of the right forearm and hand, which developed after the use terlipressin used to treat bleeding oesophageal varices in a 65-year-old man with cirrhosis.

CONCLUSIONS: Although rare, ischemic complications of terlipressin do occur.

Keywords: Biopsy, Diagnosis, Differential, Forearm, Gastrointestinal Hemorrhage - drug therapy, Lypressin - therapeutic use, Necrosis - pathology, Skin Diseases - pathology, Vasoconstrictor Agents - therapeutic use

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923