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17 June 2015 : Case report  USA

Malignant Hypertension and Thrombotic Thrombocytopenic Purpura: False Friends

Challenging differential diagnosis, Rare disease

Hossam AbdallaABCDEF, Mostafa AlfishawyC, Michael BabigumiraB, Tayyaba BashirA

DOI: 10.12659/AJCR.892787

Am J Case Rep 2015; 16:374-376

Abstract

BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is a rare hematologic disorder resulting in hemolysis of red blood cells, consumption of platelets, and occlusion of microvasculature. Malignant hypertension is the clinical syndrome of severe elevations in blood pressure and funduscopic hypertensive retinopathy, including bilateral flame-shaped hemorrhage and papilledema.

CASE REPORT: We describe the case of a 63-year-old man who presented with features of TTP and malignant hypertension treated with plasma exchange and developing end-stage renal disease.

CONCLUSIONS: Given the diagnostic uncertainty at presentation, clinicians should quickly intervene to control hypertension and institute plasma exchange as needed.

Keywords: Blood Pressure - physiology, Biopsy, Diagnosis, Differential, Hypertension, Malignant - physiopathology, Purpura, Thrombotic Thrombocytopenic - physiopathology

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923