24 June 2015
: Case report
Rheumatoid Arthritis as a Therapeutic Challenge in a Patient with Lynch Syndrome
Challenging differential diagnosis, Unusual setting of medical care, Rare disease
Hossam AbdallaABCDEF, Arindam BagchiBCD, Sabiha BandagiADDOI: 10.12659/AJCR.892906
Am J Case Rep 2015; 16:390-392
Abstract
BACKGROUND: Lynch syndrome (LS) is an inherited colorectal cancer (CRC) syndrome accounting for about 3–5% of all cases and involves significantly higher risk of subsequent malignancies, colonic as well as extra-colonic. Increased risk of malignancies, especially lymphoid malignancies, have been described in patients with autoimmune diseases like rheumatoid arthritis (RA), systemic lupus erythematosus, and Sjögren’s syndrome. Epidemiological studies demonstrated that hematopoietic, lung, skin, and prostate cancers are increased in RA, while breast and colon cancers are decreased, with an overall slight increase in all cancers.
CASE REPORT: Our case demonstrates the development of CRC, endometrial cancer, and breast cancer as a presentation of LS in a patient with RA and presents a therapeutic challenge for RA treatment.
CONCLUSIONS: We describe a patient with LS and RA presenting a therapeutic challenge because biologic agents commonly used to treat severe RA need to be used cautiously in patients with history of malignancy.
Keywords: Arthritis, Rheumatoid - diagnosis, Colonoscopy, Colorectal Neoplasms, Hereditary Nonpolyposis - therapy, Combined Modality Therapy
In Press
27 Jan 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938548
26 Jan 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938169
26 Jan 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.939026
26 Jan 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938982
Most Viewed Current Articles
13 Jul 2022 : Case report
DOI :10.12659/AJCR.936441
Am J Case Rep 2022; 23:e936441
06 Dec 2021 : Case report
DOI :10.12659/AJCR.934406
Am J Case Rep 2021; 22:e934406
23 Feb 2022 : Case report
DOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250
17 Feb 2022 : Case report
DOI :10.12659/AJCR.934399
Am J Case Rep 2022; 23:e934399