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14 September 2015 : Case report  Australia

Amiodarone-Induced Life-Threatening Refractory Hypotension

Unusual clinical course, Unusual or unexpected effect of treatment, Unexpected drug reaction

Deepak DoshiABCDE, Ravi JayawardanaABDF

DOI: 10.12659/AJCR.893920

Am J Case Rep 2015; 16:617-620

Abstract

BACKGROUND: Amiodarone is frequently used in emergency departments for treatment of arrhythmias. Incidence of several amiodarone-related adverse events is unknown. The literature is sparse for potentially life-threatening adverse effects of amiodarone.

CASE REPORT: We present a case of a male patient who presented with chest discomfort and rapid atrial fibrillation. He was known to have paroxysmal atrial fibrillation, which did not respond to initial beta-blocker treatment. The second-line drug amiodarone was given to the patient for rate control. He developed severe hypotension related to amiodarone and required inotropic support along with rapid-sequence intubation.

CONCLUSIONS: Intravenous amiodarone can cause severe and refractory hypotension.

Keywords: Amiodarone - adverse effects, Anti-Arrhythmia Agents - adverse effects, Atrial Fibrillation - drug therapy, Hypotension - chemically induced

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923