29 January 2016
: Case report
Remission of Severe Myasthenia Gravis After Massive-Dose Vitamin D Treatment
Unusual or unexpected effect of treatment, Unexpected drug reaction , Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Flávio Adsuara CadegianiABCDEFGDOI: 10.12659/AJCR.894849
Am J Case Rep 2016; 17:51-54
Abstract
BACKGROUND: Vitamin D has been shown to be related to autoimmune diseases, such as multiple sclerosis and psoriasis. Correlations have been reported between vitamin D levels and prevalence and severity of other autoimmune disorders, and also between vitamin D therapy and disease improvement and remission.
CASE REPORT: This is a case report of a patient with severe and refractory myasthenia gravis (MG) who followed a “high-dose vitamin D treatment”, a massive-dose treatment (80 000 to 120 000 IU/day) promoted by a medical center in Brazil (but still not proven), and she had her first complete remission after this type of treatment with increased vitamin D serum levels (400 to 700 ng/mL).
CONCLUSIONS: This case report may reinforce the reported correlation between vitamin D level and disease severity and introduces a possible new use for vitamin D as a potential target for treating autoimmune diseases. We recommend large, double-blind, placebo-controlled, randomized studies using high-dose vitamin D treatment for refractory autoimmune diseases to reliably assess this pharmacotherapy target for these diseases.
Keywords: Dose-Response Relationship, Drug, Myasthenia Gravis - drug therapy, Remission Induction, Severity of Illness Index, Vitamin D - administration & dosage, Vitamins - administration & dosage
SARS-CoV-2/COVID-19
31 January 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.937955
18 January 2023 : Case report
Am J Case Rep 2023; 24:e938667
30 December 2022 : Case report
Am J Case Rep 2022; 23:e938571
22 December 2022 : Case report
Am J Case Rep 2022; 23:e938003
In Press
01 Feb 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938498
31 Jan 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.937955
31 Jan 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938889
27 Jan 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938548
Most Viewed Current Articles
13 Jul 2022 : Case report
DOI :10.12659/AJCR.936441
Am J Case Rep 2022; 23:e936441
06 Dec 2021 : Case report
DOI :10.12659/AJCR.934406
Am J Case Rep 2021; 22:e934406
23 Feb 2022 : Case report
DOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250
17 Feb 2022 : Case report
DOI :10.12659/AJCR.934399
Am J Case Rep 2022; 23:e934399