18 July 2016
: Case report 
Methemoglobinemia in a Pediatric Oncology Patient Receiving Sulfamethoxazole/Trimethoprim Prophylaxis
Unusual or unexpected effect of treatment, Unexpected drug reaction, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Timothy G. CarrollABCDEF, Megan G. CarrollABCDEFDOI: 10.12659/AJCR.897820
Am J Case Rep 2016; 17:499-502
Abstract
BACKGROUND: Methemoglobinemia due to the administration of sulfamethoxazole/trimethoprim has been documented in a series of case reports. However, all of these reports are on adult patients, and all patients received at least daily administration of sulfamethoxazole/trimethoprim for the treatment of active or suspected infection.
CASE REPORT: Herein we report the development of methemoglobinemia in a pediatric patient receiving sulfamethoxazole/trimethoprim three times weekly for the prophylaxis of opportunistic infections.
CONCLUSIONS: The clinician should always consider sulfamethoxazole/trimethoprim, even when administered for opportunistic infection prophylaxis at reduced doses and intervals, as a possible cause of methemoglobinemia.
Keywords: Leukemia, Myelomonocytic, Juvenile - complications, Methemoglobinemia - chemically induced, Opportunistic Infections - prevention & control, Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
In Press
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.946515
Case report 
Am J Case Rep In Press; DOI: 10.12659/AJCR.946523
Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.947489
Case report 
Am J Case Rep In Press; DOI: 10.12659/AJCR.946626
Most Viewed Current Articles
21 Jun 2024 : Case report
98,142
DOI :10.12659/AJCR.944371
Am J Case Rep 2024; 25:e944371
07 Mar 2024 : Case report
52,847
DOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
20 Nov 2023 : Case report 
33,265
DOI :10.12659/AJCR.941424
Am J Case Rep 2023; 24:e941424
18 Feb 2024 : Case report 
23,688
DOI :10.12659/AJCR.943030
Am J Case Rep 2024; 25:e943030