Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

12 October 2016 : Case report  South Korea

A case of Primary Bone Anaplastic Large Cell Lymphoma

Challenging differential diagnosis, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Kyung Hyun KimE, Yun Hwa JungAE, Chi Wha HanE, In Sook WooE, Jong ho SonE

DOI: 10.12659/AJCR.898743

Am J Case Rep 2016; 17:734-738

Abstract

BACKGROUND: Anaplastic large cell lymphoma (ALCL) is a relatively rare subtype of non-Hodgkin’s lymphoma (NHL). Like other types of NHL, ALCL primarily involves the nodal area, and sometimes it can involve several extra-nodal sites such as skin, soft tissue, and lungs. However, extensive bone involvement in cases of ALCL is very rare whether it is primary or secondary. Without nodular involvement, ALCL can be misdiagnosed as bone tumor or metastatic carcinoma such as lung, breast, or prostate cancer, which frequently spread to bone.

CASE REPORT: A 52-year-old woman with generalized pain and 2 months of fever of unknown origin presented to our institution. After extensive evaluation, only multiple osteolytic bone lesions with periosteal soft tissue reaction were identified. Repeated core needle biopsy revealed only inflammatory cells with histiocytic reactions. After pathologic and chromosomal analysis of sufficient tissue, which was acquired from incisional biopsy, primary bone ALCL was confirmed.

CONCLUSIONS: Clinicians should keep in mind that ALCL can present with extensive bone involvement without nodal involvement.

Keywords: Bone Neoplasms - pathology, Antineoplastic Combined Chemotherapy Protocols, Cyclophosphamide, Lymphoma, Large-Cell, Anaplastic - pathology, Prednisone, Tomography, X-Ray Computed, Vincristine, Whole Body Imaging

Add Comment 0 Comments

In Press

Case report  Italy

Morbihan Disease: A Rare Case of Periorbital Bilateral Edema with Histopathological Findings of Chronic Inf...

Am J Case Rep In Press; DOI: 10.12659/AJCR.943421  

Case report  Poland

Lung Lesions: Differential Diagnoses Beyond Cancer

Am J Case Rep In Press; DOI: 10.12659/AJCR.943798  

Case report  USA

Sinus Node Dysfunction Triggered by Tonsillar Abscess: Effects of Vagal Nerve Compression

Am J Case Rep In Press; DOI: 10.12659/AJCR.943944  

Case report  China (mainland)

Genome Sequencing Analysis of a Rare Case of Blood Infection Caused by Flavonifractor plautii

Am J Case Rep In Press; DOI: 10.12659/AJCR.943920  

Most Viewed Current Articles

07 Mar 2024 : Case report  USA 37,955

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

10 Jan 2022 : Case report  Germany 31,037

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia 17,673

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

23 Feb 2022 : Case report  USA 17,528

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923